俞雁,女,1964年生于上海,博士、教授、博士生导师。本科毕业于华东师范大学,获生物学学士学位;博士毕业于美国纽约大学Mount Sinai医学院,获生物医学博士学位;在美国康奈尔大学医学院药学系完成博士后训练。2004年入职上海交通大学担任教授、博士生导师、同时担任上海市兽医生物技术重点实验室研究员、癌基因及相关基因国家重点实验室兼职研究员。2005年-2015年期间担任学院院长助理/副院长分管国际交流和实验室建设。主讲博士生“动物生物技术”和本科生“分子生物学”课程 - 2014年获上海交通大学全英语课程认证。科研方面主要从事组织再生分子机理研究以及相关药物研发,承担国家科技攻关重大专项、“863”计划项目、国家自然科学基金、上海市科委重大科技攻关等多项科研项目。<br><br>近五年发表论文:<br>1. Guan W, Yu XL, Li JJ, Deng Q, Zhang Y, Gao J, Xia P, Yuan YS, Gao J, Zhou L, Han W, Yu Y. Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice. Experimental and Therapeutic Medicine 2017 14:1001-1008<br>1.Xia P, Gao J, Guan W, Li JJ, Yu XL, Wang FY, He HL, Deng Q, Zhou L, Yuan YS, Han W, Yu Y. Production of bioactive recombinant rat soluble receptor for advanced glycation end products (rrsRAGE) in Pichia Pastoris. Protein Expression and Purification, 2017 138:81-87 <br>2.Xia P, Deng Q, Gao J, Yu XL, Zhang Y, Li JJ, Guan W, Hu JJ, Tan Q, Zhou L, Han W, Y. Yuan YS, Yu Y. Therapeutic effects of antigen affinity-purified polyclonal anti-receptor of advanced glycation end-products(anti-RAGE) antibodies on cholestasis-induced liver injury in rats. European Journal of Pharmacology, 2016 779:102-110<br>3.Zhang Y, Gao J, Wang X, Deng S, Ye H, Guan W, Wu M, Zhu S, Yu Y & Han W. CXCL4 mediates tumor regrowth after chemotherapy by suppression of antitumor immunity. Cancer Biol Ther. 2015 16:1775-83<br>4.Guan W, Deng Q, Yu XL, Yuan YS, Gao J, Li JJ, Zhou L, Xia P, Han GY, Han W & Yu Y. Blockade of S100A3 activity inhibits murine hair growth. Genet Mol Res. 2015 14:13532-44 <br>5.Wang X, Gao J, Qian L, Gao J, Zhu S, Wu M, Zhang Y, Guan W, Ye H, Yu Y & Han W. Exogenous IL-1Ra attenuates intestinal mucositis induced by oxaliplatin and 5-fluorouracil through suppression of p53-dependent apoptosis. Anticancer Drugs. 2015 26:35-45 <br>6.Xu C, Zhu S, Wu M, Zhao Y, Han W, Yu Y. The Therapeutic Effect of rhMK on Osteoarthritis in Mice, Induced by Destabilization of the Medial Meniscus. Biol Pharm Bull. 2014 37:1803-10<br>7.Yuan Y. Zhang X. Weng S. Guan W. Xiang D. Gao J. Li J. Han W & Yu Y. Expression and purification of bioactive high-purity recombinant mouse SPP1 in Escherichia coli. Applied Biochemistry and Biotechnology 2014 173:421-32<br>8.Xu C, Zhu S, Wu M, Han W & Yu Y. Functional receptors and intracellular signal pathways of midkine (MK) and pleiotrophin (PTN). Biol Pharm Bull. 2014 37:511-20<br>9.Gao J, Jin G, Qian L, Wang X, Wu MY, Zhang Y, Zhu SY, Yu Y & Han W. Activation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluouracil. Cancer Biology & Therapy 2014 15:1-10<br>10.Wang X, Zhu SY, Qian L, Gao J, Wu MY, Jin G, Zhang Y, Chan GL, Yu Y & Han W. IL-1Ra selectively protects intestinal crypt epithelial cells, but not tumor cells, from chemotoxicity via p53-mediated upregulation of p21WAF1 and p27KIP1. Pharmacological Research 2014 82:21-33